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National Repository of Grey Literature 1 records found  Search took 0.00 seconds. 
General stress response in Staphylococcus aureus and its role in adaptation to hyperosmotic stress
 Kotková, Hana ; Lichá, Irena (advisor) ; Seydlová, Gabriela (referee)
Hyperosmotic stress induces a stress reponse in a halotolerant bacteria Staphylococcus aureus that helps it to survive even the osmotic conditions that are inhibiting for most of the bacteria. Stress responses of S. aureus include a general stress response that activates rapidly on a wide range of stresses and is ensured by expression of genes induced by an alternative sigma B subunit of RNA polymerase (SigB), and more specific responses to hyperosmotic stress associated with transporters of potassium and transporters of compatible solutes. Also, some virulence factors (such as the adhesive Ebh protein) allow S. aureus to survive hyperosmotic stress within the host, thereby helping to colonize it. It is currently known that the general stress response directly and indirectly participates in the specific stress adaptation through the Kdp transport system for potassium (Kdp transporter) and transporters of compatible solutes (PutP and OpuD). Expression of the Kdp transporter and the large S. aureus Ebh protein is SigB dependent, via Agr or ArlRS virulence regulator systems. The formation of a biofilm, in which SigB is significantly involved, may also enable to colonize host niches with low water activity. Hyperosmotic stress by triggering SigB initiates a complex response that is associated not only...
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